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Rheumatoid Arthritis | What is seronegative rheumatoid arthritis?


What is seronegative rheumatoid arthritis?
“Seronegative” means rheumatoid factor is not present in the blood.
Rheumatoid factor is a protein found in the blood of 80% of people with rheumatoid arthritis.
That means 20% of people with RA don’t have rheumatoid factor (duh)!
But… there are many other kinds of arthritis that can look like rheumatoid arthritis! Which
means a careful diagnostic workup is needed to be absolutely sure it really is seronegative
RA! Just to be sure! The good news is that seronegative RA is treated
just like seropositive RA! And… it appears to have a better prognosis!

4 thoughts on “Rheumatoid Arthritis | What is seronegative rheumatoid arthritis?

  1. Thanks for the great info, Dr. What kind of work up would you recommend to rule out or confirm this diagnosis? I am in a gray area in terms of my diagnosis. I have been diagnosed by one very well known rheumatologists as having Spondyloarthropathy, another disagreed and assumed it was more like fibermogalyia and my most current Dr. has stated that it is degenrative arthritis and that I shouldn't be responding to biolgics based on my XRay's/MRI's but they have been life savers outside of the pain associated with injections. Also, another MD (not a rheumatologist) who read a 2012 MRI of the spine suggested that metastasis should be considered based on the degeneration of the thoracic spine. Recent Spine XRays showed no signs of cancer. I have no instance of HLA-B27 (negative), as well as negative rheumatoid factor. Negative ANA (ELISA) but that was done in 2008. Most recently, I have had a swollen ankle that doesn't respond to anything and has been consistent for over a year. Catscan, XRays and MRI indicate the same thing–mild effusion but everything is intact. Current Doc tells me that it's just arthritis and continues to put a band aid around the problem with anti-inflammatory meds. Thanks in advance for any feedback. I really appreciate your time!

  2. hey ,if anyone else needs to find out about
    arthritis and joint health
    try Knewreck Arthritis Treatment Guide (Have a quick look on google cant remember the place now ) ? Ive heard some awesome things about it and my buddy got great results with it.

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